Metformin Treatment is Associated with Mortality in Patients with Type 2 Diabetes and Chronic Heart Failure in the Intensive Care Unit: A Retrospective Cohort Study

Objective: Patients receiving intensive care often have diabetes mellitus (DM) together with chronic heart failure (CHF). In these patients, the use of metformin in is controversial. This study was aimed at assessing mortality rates patients DM and CHF treated metformin. Methods: The Medical Information Mart for Intensive Care database used to identify type 2 (T2DM) CHF. A 90-day comparison conducted between who were not administered Propensity score matching analysis multivariable Cox proportional hazard regression ensure robustness our results. Results: total 2153 (180 1973 metformin) T2DM included study. 30.5% (601/1971) 5.5% (10/182) non-metformin groups, respectively. propensity analyses, associated a 71% lower (hazard ratio, 0.29; 95% confidence interval, 0.14–0.59; P < 0.001). results insensitive change when sensitivity analyses performed. Conclusion: Metformin treatment may decrease risk critically ill unit.